Does maternal weight gain in pregnancy have long-term effects on offspring adiposity? A sibling study in a prospective cohort of 146,894 men from 136,050 families.

نویسندگان

  • Debbie A Lawlor
  • Paul Lichtenstein
  • Abigail Fraser
  • Niklas Långström
چکیده

BACKGROUND A small number of relatively small studies have found greater gestational weight gain to be associated with greater offspring body mass index (BMI; in kg/m(2)), but whether this association is caused by intrauterine mechanisms or by shared genetic and environmental risk factors for adiposity is unclear. OBJECTIVE The objective was to examine the association of greater maternal weight gain (MWG; postnatal weight minus weight at the first antenatal clinic assessment) with greater offspring BMI and to explore whether any observed association is explained by intrauterine mechanisms. DESIGN This was a prospective cohort study that used record linkage data (n = 146,894 individuals from 136,050 families). To compare the within-sibling and between-nonsibling associations, we used fixed- and between-cluster linear regression models. RESULTS Associations of MWG with later offspring BMI differed by the mother's early-pregnancy overweight or obesity status (P for interaction <0.0001). MWG was positively associated with BMI at a mean age of 18 y in the offspring of normal-weight women but only between unrelated men (0.07; 95% CI: 0.06, 0.07) per 1-kg greater MWG; no within-sibling association (0.00; 95% CI: -0.02, 0.02) per 1-kg greater MWG was found. In contrast, in overweight and obese women we found a within-sibling association (0.06; 95% CI: 0.01, 0.12) and an association between unrelated men (0.02; 95% CI: 0.01, 0.03) per 1-kg greater MWG. CONCLUSION In normal-weight mothers, most of the association between MWG and later offspring BMI is explained by shared familial (genetic and early environmental) characteristics, whereas evidence indicates a contribution of intrauterine mechanisms in overweight and obese women.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Association of maternal diabetes mellitus in pregnancy with offspring adiposity into early adulthood: sibling study in a prospective cohort of 280,866 men from 248,293 families.

BACKGROUND Maternal diabetes mellitus in pregnancy results in greater offspring adiposity at birth. It is unclear whether it is associated with greater adiposity into adulthood, and if so, whether this is via intrauterine mechanisms or shared familial characteristics. METHODS AND RESULTS A record-linkage prospective cohort study of 280,866 singleton-born Swedish men from 248,293 families was ...

متن کامل

Association of Maternal Diabetes Mellitus in Pregnancy With Offspring Adiposity Into Early Adulthood

Background—Maternal diabetes mellitus in pregnancy results in greater offspring adiposity at birth. It is unclear whether it is associated with greater adiposity into adulthood, and if so, whether this is via intrauterine mechanisms or shared familial characteristics. Methods and Results—A record-linkage prospective cohort study of 280 866 singleton-born Swedish men from 248 293 families was us...

متن کامل

High-protein diets during pregnancy: healthful or harmful for offspring?

Maternal diet during pregnancy can induce developmental adaptations that permanently alter offspring physiology and metabolism (1). Fetal programming is an important risk factor for obesityand adiposity-related noncommunicable diseases in adult life (1). The influence of maternal dietary protein during pregnancy on offspring phenotype and health is generating research interest (2, 3). Both low-...

متن کامل

Epidemiology and Prevention Association of Maternal Weight Gain in Pregnancy With Offspring Obesity and Metabolic and Vascular Traits in Childhood

Background—We sought to examine the association of gestational weight gain (GWG) and prepregnancy weight with offspring adiposity and cardiovascular risk factors. Methods and Results—Data from 5154 (for adiposity and blood pressure) and 3457 (for blood assays) mother-offspring pairs from a UK prospective pregnancy cohort were used. Random-effects multilevel models were used to assess incrementa...

متن کامل

Association of maternal weight gain in pregnancy with offspring obesity and metabolic and vascular traits in childhood.

BACKGROUND We sought to examine the association of gestational weight gain (GWG) and prepregnancy weight with offspring adiposity and cardiovascular risk factors. METHODS AND RESULTS Data from 5154 (for adiposity and blood pressure) and 3457 (for blood assays) mother-offspring pairs from a UK prospective pregnancy cohort were used. Random-effects multilevel models were used to assess incremen...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The American journal of clinical nutrition

دوره 94 1  شماره 

صفحات  -

تاریخ انتشار 2011